Resist virus _ of hepatitis B to treat with some

Resist virus _ of hepatitis B to treat with some
Hepatitis B and virus (HBV) The infection is infectious disease of a kind of global distribution. 1.2- 1.3 hundred million people are infected with hepatitis B and virus, the chronic hepatitis B patient (CHB) among them in China About 3000- 3500 ten thousand people, have among them 10% - 40% Can develop into liver cirrhosis, 1% - 5% can develop into hepatocarcinoma. Die of hepatopathy of relevance every year ' Including hepatocarcinoma) About 50- 80 ten thousand people. Hepatitis B and virus are if through infecting vertically or infecting in baby period, more than 90% will become the chronic person who carries HBsAg, it is monobasic and healthy, very harmful to influence seriously.
As to the infeted of hepatitis B and virus, with what on earth do we come antiviral?
Idea
At present to chronic the intersection of hepatitis B and treatment of patient, to adopt antiviral, immune adjustment, improve liver function and resist the intersection of liver and the intersection of fiber and the intersection of person who take and composite treatment, but the key among them is an antiviral treatment. This is duplication that because the antiviral treatment not merely can inhibit the virus; Can improve liver function and the intersection of liver and inflammation, necrosis and fiber, take pathological change; Still can improve the intersection of life and quality of patient and it reduces their to be infective, make the virus remove finally, stop the emergence, development of pathological change, make the disease decrease and repair, it is depleted to block, develop into liver cirrhosis, liver function and hepatocarcinoma. This is nowadays opposing the new idea of virus treatment of hepatitis B.
Recalled in the past, our mistaken ideas existed, blind spot in treating hepatitis B and virus, not a few.
Pay attention to, resist the intersection of hepatitis B and the intersection of virus and treatment, think transaminase (ALT) by mistake at first Unusual to brief on, have infective index, think transaminase to be high, it is strong to be infective. Unfortunately, hold such wrong view, still such people are by no means rare now. They only pay attention to lowering transaminase, do not considering the antiviral treatment; In choosing antivirally to treat the opportunity, always take measures to drop transaminase to normally first, or being antiviral while treating, the enzyme medicine falls by uniting benzene one pair of esters,etc. strongly to add. This makes a lot of patients miss the best therapeutic opportunity.
On choice and method against virus medicine of hepatitis B, some doctors or patients, unwilling to accept internationally acknowledged antiviral first-selected medicine - interferon, time select the new nucleoside analog of medicine, and accept the antiviral treatment of traditional Chinese medicine year in year out, or only want with a certain medicine, solve the problem within short time, the result can only be to end in failure. Not only contribute to the losses that in economy for the patient, but also make them suffer the setback greatly on spirit like this, after being sad and disappointed, some still obtain " hepatitis B is unable to manage " Conclusion,with paralrzed oneself.
Medicine
Today, science developed rapidly, in resisting the virus treatment of hepatitis B, have already obtained a lot of new progress. Present therapeutic method mainly locks the following three kinds:
( 1) Use - interferon with the intersection of nucleoside and similar antiviral medicine, the intersection of Lammi and make, the intersection of A and Wei, the intersection of kindness and the intersection of ground and the intersection of card and Wei,etc., good fortune of Germany, resist the virus treatment of hepatitis B;
( 2) With the cell factor such as thymosin 1, lie between plain 12, - interferon etc. in vain, carry on the non- specific immune adjustment treatment;
( 3) Adopt and resist HBV treatment vaccine, carry on specific immunization therapy.
The specific immune treatment is really a kind of brand-new treatment for hepatitis B and virus, it features the immunity that it can break the infeted of chronic hepatitis B and virus is tolerated, that is to say that can also accept this kind of treatment under the situation not high of GPT.
In our country, the specific immune treatment was approved by Chinese Health Ministry in September of 1998, cooperated in the group by association's clinical research of China's medical biotechnology, organize the unit concerned to adopt the gene to recombinate the surface antigen of hepatitis B (HBsAg) Therapeutic vaccine made. Successively observing and treating 370 persons who carries virus of chronic hepatitis B, made HBsAg, HBeAg and HBV DNA overcast rotating rate up to 14.7%, 30.0% and 37.3% respectively, curative effect is better, compared with control group in the same term, the difference is prominent. This kind of method is still very safe, the side reaction that has made the patient be unable to tolerate has not happened so far, worth further studying, at present, are working hard for can reach the total goal which has resisted hepatitis B treatment ing.
Prospect
At the 39th Meeting of European hepatopathy held in April of 2004, there are experts that reported: Use the intersection of A and Wei, good fortune of Germany, separately, can make some patients HBsAg, HBV DNA turn overcast, ALT returns to normal. Treat with good fortune of A Germany the intersection of esterification and thing Wei in the course, 90% more than patient can keep HBeAg serum changing one year.
In addition, gather second 2 refine the intersection of interferon and - 2a (send Luo happy) Use separately, can produce than Lammi too the makes the high lasting response rate. I unite thymic peptide with this medicine- 1 (base is safe) To treat is slow by hepatitis B 6, among them turn already overcast for a example of HBsAgs,another an HBsAg too already from before treating strong and positive, it is weak and positive while treating for 5 months. Have seemed to demonstrate better symptom tentatively. If can cooperate with above-mentioned peculiar treatment vaccine again, its curative effect will be better.
It is reported, DNA vaccine, tree which our country is developing as soon as possible dash for ward treatment vaccine such as vaccine at present, have a good prospect. So, though there is difficult and much future, the hepatitis B patient don't be disappointed for this, because science and technology is always advancing, will be better than definitely today tomorrow.
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