The biological angle is seen " The hepatocarcinoma treatment " 's treatment

The biological angle is seen " The hepatocarcinoma treatment " 's treatment
Close to one century in the past, the treatment of hepatocarcinoma of medical circle was set up on the pathological basis. Pathology main research cancer cell, the goal of the treatment is to eliminate tumour, cancer cell, mainly have surgery, radiotherapy, chemotherapy, the part is treated, treatment means of getting involved and treating etc., and tumour in order to control is always efficient to come as the index of appraising therapeutic method.
By the 1990s last century, biology began to influence the hepatocarcinoma treatment too, the present treatment had pathology and biological characteristic concurrently. Stand on the biological angle looking, the target of studying in treatment of cancer is not merely a cancer cell, but the whole made up of organism hereditary condition, internal microenvironment and cancer cell, appraise one therapeutic method from biological angle, it depends on total life cycle in patient, include the patient's time to take tumour to survive. Molecule target biological main application means of to treat, not immune gene therapy,etc..
The expert says, examine and cure the improvement greatly of result that undoubtedly made the operation excise hepatocarcinoma early early. Exceed 3 or two the intersection of cancer and the intersection of tubercle and diameter single the intersection of cancer and the intersection of tubercle and most large diameter at the clinic and hepatocarcinoma under 3 centimetres is called light hepatocarcinoma, after it perform the operation to excise at present the patient on the five year last 57.3% survival rate already,but if,etc. develop until big hepatocarcinoma finding by conditioning and excising operation, survival rate is only 30.9% in five years.
The expert points out, the operation was excised for five years of hepatocarcinoma survival rate has already been close to the high limit, the space improved does not seem big. Take little hepatocarcinoma excision which the research institute of hepatocarcinoma of Fudan University has made as examples, 5 only 1/3 of survival rate between 1974 and 1958, and was up to 55.2% from 1974 to 1989. But from 1989 to 2005, figure this rise several percentage point only, explain surgery, excise little therapeutic effect of hepatocarcinoma, already close to their high limits, other therapeutic method such as radio frequency, liver transplantation,etc. has met this question too. The expert still shows, there are very high invasion and attack, transformation or latent energy of recuring even if it is small hepatocarcinoma, so examine and manage and can't solve the problem completely early early.
So, the expert thinks, in view of biological angles, there should be higher requirements in the hepatocarcinoma treatment, should direct against tumour, should direct against residual tumour cells too, " hepatocarcinoma is some pathological change, it is pathological change of the whole body even more, it is a long-term therapeutic direction that the ones that give consideration to patient's nerve, endocrine, supersession, immune system will be treated synthetically all over. "
The transformation of cancer lets many tumour patients and relatives strike torror at the mere mention of it, but the expert says, the medical circle utilizes a model system of metastasis of cancer of liver set up in 12 years to find, the microenvironment in laboratory little mouse's body can obviously change the biological characteristic of cancer, "it means cancer may make the condition deteriorate to shift to attack, may make the condition become well too, complex treatment in the future expected to can let cancer cell that shift ' turn respectable '. " He says, complex treatment different modes are still at at the beginning at present at the same time, there are still relatively few ones that were proved through following medical science of card, but it will be the trend that the future will be studied to study complex treatment from the biological angle.
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