's general knowledge of pathogenesis of hepatitis A

's general knowledge of pathogenesis of hepatitis A
Study less about the morbidity mechanism of the first type hepatitis, has not totally expounded yet. After the mouth infects HAV, have transient virus blood disease stage before the onset, then orientate as the liver. Think previously HAV damages function directly. Research shows in recent years: Experimental no cell pathological change will take place while infecting the external cell cultivation of animal hepatocyte and HAV of HAV; Patient +8 the intersection of cell and inferior group, CD of serum, increase, cause quick lymphocyte reveal the cell to hepatocyte that HAV is infect; The inflammatory response is obvious,etc. in the liver. According to the result of study, think, it has illness coming on the mechanism inclines to take host's immunoreaction as the core at present. Early period such as onset, because HAV proliferate in a large amount in hepatocyte and CD +8 the intersection of cell and toxic the intersection of T and cell wound function, lead to the fact the hepatocyte to damage jointly perhaps, the disease may rely mainly on the fact that immune pathology is damaged on later stage.
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