Hepatitis A and virus and anaphylactic _'s general knowledge

Hepatitis A and virus and anaphylactic _'s general knowledge
Researchers write articles to point out on Nature,Hepatitis A and virus (HAV) The infection rate can lead to the fact peculiar reactive disease increases while reducing.

Asthma, anaphylactic rhinitis and anaphylactic dermatitisWait for the anaphylaxisDisease is initiated by the environment acts on the inherent cause together.

Exposed to HAV usually and the intersection of sanitary condition and bad, big family, reach day-care center to be in close relations,And capital and anaphylaxis of these factorsDisease is presented and shouldered relevantly.

For this reason,American researchers have canvassed hepatitis A and virus to infect and preventThe anaphylaxis takes place to the patientDisease.

Little the intersection of mouse and size 11 as anaphylaxis TIM-1 at the chromosome research groupThe alternative genes of disease and asthma, this gene and people's chromosome 5q31-33 passage are (in close relation with anaphylactia) Have homology nature.

The research group has investigated whether HAV and TIM could make T cells present the change to the interaction of lymphocytes, thus prevent the anaphylaxisDisease. At the same timeCheck large attitude performance of TIM-1 deny and change the anaphylaxis alsoDisease is easy to be perceptual.

Researchers have found the 157th amino acid residues6 amino acid be lasted ( 157insMTTTVP) to be inserted in With 2 single amino acid changes. In order to canvass 157insMTTTVP influence on peculiar reactive disease takes placing, the research group has appraised 375 and measured anaphylaxisDisease, combining the patient who has infected HAV.

The research group finds, HAV serum is positive to the anaphylaxisDisease has protective action. However, this protective action only appears having TIM-1 157insMTTTVP mutant individuals.

Researchers point out, before 1970, resisting the positive rate of HAV antibody serum and was up to 100% of the western countries. So, HAV can make a lot of patients not happen to infectAnaphylaxisDisease.

However, household sizeReduce making with the improvement of the public health and resist the positive rate of HAV serum to drop to 25-30%, at the same time, anaphylaxisThe morbidity of disease doubles.

The interaction of HAV and TIM-1 genotype is not the anaphylaxis through being possibleThe cause of disease of disease, can also be regarded as and explained this disease at the same timeMechanism of the hypothesis.

Dr. Jennifer McIntire thinks,Exposed to causing quickly and originallyCan influence the anaphylaxisAppearance of disease. HAV infection rate can unite function with TIM-1 to reduce, makes peculiar reactive disease increase.

McIntire Dr. think, need, canvass the intersection of children and issue, must exposed to HAV so as to produce protective action not merely in the future, and need to study HAV and lightening the anaphylaxis that has already appearedWhether the severity, HAV vaccine inoculation of disease could duplicate the result that natural HAV infect.
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