's general knowledge of aetiology of hepatitis A

's general knowledge of aetiology of hepatitis A
HAV is RNA virus in aetiology and molecular biology, belong to the small RNA virus department, think originally that belongs to the 72 type intestinal virus, thinking now that should list separately belongs to (the virus of liver belongs to) . Because HAV has the following characteristics:
Have a liking for the liver;
Cells train cycle long, seldom cause cell pathological change;
The virus lies in cells, seldom release outside cells;
Heat-resisting, it is infective that 60 1 is little to still have.
HAV-RNA genome only includes 38% guanine and adenine nucleotide, is well below other intestinal virus.
HAV trains success in the external organization. Mainly duplicate in liver essence cells, has not proved yet that there are only a serum type and an antigenic antibody system at present to duplicate in other tissues.
About HAV genotype, HAV some genome complementary DNA (cDNA) of 1981 Have already been cloned, has already clearly studied about wild poisonous HAV genome nucleotide arrays at present. HAV genome (HAV-RNA) Made up of 3 parts:
5#39; -The not encoding area, it is first period of to lie in genome, duplicate important meaning to HAV;
The code district, open and read one yard of frames (ORF) ,Only this code gets albumens together;
3#39; -The not encoding area, lie behind ORF, there is no function of encoding the virus albumen. According to their arrays of genome, can be divided into 7 genotypes. It is human it can divide into HAV for, 2, and,majority is and type,only poisonous specific is for 2 and. Monkey HAV it divides into to be and with type. Several HAV genotypes of ones that separate from our country are the same. Know now HAV not only morphs in the nature, but also can train and go down to posterity to induce producing the gene mutation one in succession through animals or cells.
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